LOBSTAHS: An Adduct-Based Lipidomics Strategy for Discovery and Identification of Oxidative Stress Biomarkers.

@article{Collins2016LOBSTAHSAA,
  title={LOBSTAHS: An Adduct-Based Lipidomics Strategy for Discovery and Identification of Oxidative Stress Biomarkers.},
  author={James R Collins and Bethanie R. Edwards and Helen F. Fredricks and Benjamin A S Van Mooy},
  journal={Analytical chemistry},
  year={2016},
  volume={88 14},
  pages={
          7154-62
        }
}
Discovery and identification of molecular biomarkers in large LC/MS data sets requires significant automation without loss of accuracy in the compound screening and annotation process. Here, we describe a lipidomics workflow and open-source software package for high-throughput annotation and putative identification of lipid, oxidized lipid, and oxylipin biomarkers in high-mass-accuracy HPLC-MS data. Lipid and oxylipin biomarker screening through adduct hierarchy sequences, or LOBSTAHS, uses… CONTINUE READING
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