LNA: a versatile tool for therapeutics and genomics.

@article{Petersen2003LNAAV,
  title={LNA: a versatile tool for therapeutics and genomics.},
  author={Michael Petersen and Jesper Wengel},
  journal={Trends in biotechnology},
  year={2003},
  volume={21 2},
  pages={
          74-81
        }
}
Locked nucleic acid (LNA) is a nucleic acid analogue that displays unprecedented hybridization affinity towards complementary DNA and RNA. Structural studies have shown LNA to be an RNA mimic, fitting seamlessly into an A-type duplex geometry. Several reports have revealed LNA as a most promising molecule for the development of oligonucleotide-based therapeutics. For example, Tat-dependent transcription and telomerase activity have been efficiently suppressed by LNA oligomers, and efficient… CONTINUE READING
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