LN-1-255, a penicillanic acid sulfone able to inhibit the class D carbapenemase OXA-48.

Abstract

OBJECTIVES Carbapenemases are the most important mechanism responsible for carbapenem resistance in Enterobacteriaceae. Among carbapenemases, OXA-48 presents unique challenges as it is resistant to β-lactam inhibitors. Here, we test the capacity of the compound LN-1-255, a 6-alkylidene-2'-substituted penicillanic acid sulfone, to inhibit the activity of the… (More)
DOI: 10.1093/jac/dkw105

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