LMW-PTP is a positive regulator of tumor onset and growth

  title={LMW-PTP is a positive regulator of tumor onset and growth},
  author={Paola Chiarugi and Maria Letizia Taddei and Nicola Schiavone and Laura Papucci and Elisa Giannoni and Tania Fiaschi and Sergio Capaccioli and Giovanni Raugei and G. Manao G. Ramponi},
Low molecular weight protein tyrosine phosphatases (LMW-PTPs) are an enzyme family that plays a key role in cell proliferation control by dephosphorylating/inactivating both tyrosine kinase receptors (such as PDGF, insulin, and ephrin receptors) and docking proteins (such, as β-catenin) endowed with both adhesion and transcriptional activity. Besides being a frequent event in human tumors, overexpression of LMW-PTP has been recently demonstrated to be sufficient to induce neoplastic… CONTINUE READING


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