LMTK3 is implicated in endocrine resistance via multiple signaling pathways

@article{Stebbing2013LMTK3II,
  title={LMTK3 is implicated in endocrine resistance via multiple signaling pathways},
  author={Justin Stebbing and Aleksandra Filipovi{\'c} and Lei Cheng Lit and Kevin Blighe and Arnhild Grothey and Y Xu and Yoshimi Miki and Louis Wing-Cheong Chow and R C Coombes and Hironobu Sasano and Jacqui A. Shaw and Georgios Giamas},
  journal={Oncogene},
  year={2013},
  volume={32},
  pages={3371-3380}
}
Resistance to endocrine therapy in breast cancer is common. With the aim of discovering new molecular targets for breast cancer therapy, we have recently identified LMTK3 as a regulator of the estrogen receptor-alpha (ERα) and wished to understand its role in endocrine resistance. We find that inhibition of LMTK3 in a xenograft tamoxifen (Tam)-resistant (BT474) breast cancer mouse model results in re-sensitization to Tam as demonstrated by a reduction in tumor volume. A whole genome microarray… CONTINUE READING