LMP1 signaling pathway activates IRF4 in latent EBV infection and a positive circuit between PI3K and Src is required

@article{Wang2017LMP1SP,
  title={LMP1 signaling pathway activates IRF4 in latent EBV infection and a positive circuit between PI3K and Src is required},
  author={L-y Wang and J Ren and Gang Li and Jonathan Patrick Moorman and Zhi Qiang Yao and Siqing Ning},
  journal={Oncogene},
  year={2017},
  volume={36},
  pages={2265-2274}
}
Interferon (IFN) regulatory factors (IRFs) have crucial roles in immune regulation and oncogenesis. We have recently shown that IRF4 is activated through c-Src-mediated tyrosine phosphorylation in virus-transformed cells. However, the intracellular signaling pathway triggering Src activation of IRF4 remains unknown. In this study, we provide evidence that Epstein–Barr virus (EBV) latent membrane protein 1 (LMP1) promotes IRF4 phosphorylation and markedly stimulates IRF4 transcriptional activity… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 55 references

IRF4 as an oncogenic biomarker for hematological malignancies

  • S. Ning
  • J Oncobiomarkers 2013;
  • 2013

Similar Papers

Loading similar papers…