LL-37-induced host cell cytotoxicity depends on cellular expression of the globular C1q receptor (p33).

@article{Svensson2016LL37inducedHC,
  title={LL-37-induced host cell cytotoxicity depends on cellular expression of the globular C1q receptor (p33).},
  author={D. Svensson and L. Wilk and M. M{\"o}rgelin and H. Herwald and B. Nilsson},
  journal={The Biochemical journal},
  year={2016},
  volume={473 1},
  pages={
          87-98
        }
}
  • D. Svensson, L. Wilk, +2 authors B. Nilsson
  • Published 2016
  • Biology, Medicine
  • The Biochemical journal
    • The human host-defence peptide (HDP) LL-37 not only displays anti-microbial activity but also immune-modulating properties that trigger intracellular signalling events in host cells. Since the cytolytic activity of high LL-37 concentrations affects cell viability, the function of LL-37 requires tight regulation. Eukaryotic cells therefore benefit from protective measures to prevent harmful effects of LL-37. p33, also known as globular C1q receptor (gC1qR), is reported to act as an LL-37… CONTINUE READING
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    18 Citations
    Background Citations
    10
    Methods Citations
    2
    Results Citations
    1
    18 Citations
    Citation Type

    Citation Type

    Regulation of human cell viability by the host defence peptide LL-37
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    LL-37-induced caspase-independent apoptosis is associated with plasma membrane permeabilization in human osteoblast-like cells
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    LL-37-induced human osteoblast cytotoxicity and permeability occurs independently of cellular LL-37 uptake through clathrin-mediated endocytosis.
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    Globular C1q receptor (p33) binds and stabilizes pro-inflammatory MCP-1: a novel mechanism for regulation of MCP-1 production and function.
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    What can we learn about functional importance of human antimicrobial peptide LL-37 in the oral environment from severe congenital neutropenia (Kostmann disease)?
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    Host modulation of excessive innate immune responses
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    The C1q Receptors: Focus on gC1qR/p33 (C1qBP, p32, HABP-1)1.
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