LL-37-induced host cell cytotoxicity depends on cellular expression of the globular C1q receptor (p33).

@article{Svensson2016LL37inducedHC,
  title={LL-37-induced host cell cytotoxicity depends on cellular expression of the globular C1q receptor (p33).},
  author={D. Svensson and L. Wilk and M. M{\"o}rgelin and H. Herwald and B. Nilsson},
  journal={The Biochemical journal},
  year={2016},
  volume={473 1},
  pages={
          87-98
        }
}
  • D. Svensson, L. Wilk, +2 authors B. Nilsson
  • Published 2016
  • Biology, Medicine
  • The Biochemical journal
  • The human host-defence peptide (HDP) LL-37 not only displays anti-microbial activity but also immune-modulating properties that trigger intracellular signalling events in host cells. Since the cytolytic activity of high LL-37 concentrations affects cell viability, the function of LL-37 requires tight regulation. Eukaryotic cells therefore benefit from protective measures to prevent harmful effects of LL-37. p33, also known as globular C1q receptor (gC1qR), is reported to act as an LL-37… CONTINUE READING
    18 Citations
    Regulation of human cell viability by the host defence peptide LL-37
    • PDF
    Apolipoprotein A-I attenuates LL-37-induced endothelial cell cytotoxicity.
    • 7
    The host defense peptide LL-37 triggers release of nucleic acids from human mast cells
    • 3
    Host modulation of excessive innate immune responses
    • PDF

    References

    SHOWING 1-10 OF 47 REFERENCES
    The human cathelicidin LL-37 preferentially promotes apoptosis of infected airway epithelium.
    • 87
    • PDF
    cC1qR/CR and gC1qR/p33: observations in cancer.
    • 38