LL-37 enhances adaptive antitumor immune response in a murine model when genetically fused with M-CSFR (J6-1) DNA vaccine.

@article{An2005LL37EA,
  title={LL-37 enhances adaptive antitumor immune response in a murine model when genetically fused with M-CSFR (J6-1) DNA vaccine.},
  author={Li-li An and Ying-hua Yang and Xiao-Tong Ma and Yong-Min Lin and Ge Li and Yu-Hua Song and Ke-fu Wu},
  journal={Leukemia research},
  year={2005},
  volume={29 5},
  pages={
          535-43
        }
}
DNA vaccine against M-CSFR(J6-1) (macrophage colony-stimulating factor receptor cloned from the J6-1 leukemic cell line) has shown both protective and therapeutic effects. In this study, to explore the adjuvant effects of LL-37 to M-CSFR(J6-1) DNA vaccines, we constructed genetically fused vaccines encoding M-CSFR(J6-1) and LL-37(pF). After immunizing BALB/c mice, specific humoral and cellular immune responses were detected. Compared with pR (encoding the extracellular region of M-CSFR(J6-1… CONTINUE READING

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