LL-37 Peptide Enhancement of Signal Transduction by Toll-like Receptor 3 Is Regulated by pH

@article{Singh2014LL37PE,
  title={LL-37 Peptide Enhancement of Signal Transduction by Toll-like Receptor 3 Is Regulated by pH},
  author={Divyendu Singh and R. Vaughan and C. Kao},
  journal={The Journal of Biological Chemistry},
  year={2014},
  volume={289},
  pages={27614 - 27624}
}
Background: How LL-37 delivers double-stranded RNA (dsRNA) to activate TLR3 signaling is poorly understood. Results: LL-37 was found to traffic to endosomes with RNA and releases the dsRNA upon endosome acidification. A peptide derived from LL-37 could antagonize LL-37·dsRNA trafficking. Conclusion: LL-37 trafficking of dsRNA is regulated by pH. Significance: This work establishes the mechanism of LL-37 enhancement of dsRNA-activated TLR3 signaling. LL-37 is a peptide secreted by human… Expand
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