LKPNM: a prodrug-type ACE-inhibitory peptide derived from fish protein.

  title={LKPNM: a prodrug-type ACE-inhibitory peptide derived from fish protein.},
  author={Hiroyuki Fujita and Masaaki Yoshikawa},
  volume={44 1-2},
It has been previously documented that the thermolysin-digest of "Katsuo-bushi", a Japanese traditional food processed from dried bonito possesses potent inhibitory activity against angiotensin I-converting enzyme (ACE). The present authors isolated eight kinds of ACE-inhibitory peptides from it. Of these isolated peptides, LKPNM (IC50 = 2.4 microM) was found to be hydrolyzed by ACE to produce LKP (IC50 = 0.32 microM) with 8-fold higher ACE-inhibitory activity relative to the parent peptide or… CONTINUE READING
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