LKLF: A transcriptional regulator of single-positive T cell quiescence and survival.

@article{Kuo1997LKLFAT,
  title={LKLF: A transcriptional regulator of single-positive T cell quiescence and survival.},
  author={Chieh Ti Kuo and Margaret L. Veselits and Jeffrey M. Leiden},
  journal={Science},
  year={1997},
  volume={277 5334},
  pages={1986-90}
}
Mature single-positive (SP) T lymphocytes enter a "resting" state in which they are proliferatively quiescent and relatively resistant to apoptosis. The molecular mechanisms regulating this quiescent phenotype were unknown. Here it was found that the expression of a Kruppel-like zinc finger transcription factor, lung Kruppel-like factor (LKLF), is developmentally induced during the maturation of SP quiescent T cells and rapidly extinguished after SP T cell activation. LKLF-deficient T cells… CONTINUE READING
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