LKB1 modulates lung cancer differentiation and metastasis

@article{Ji2007LKB1ML,
  title={LKB1 modulates lung cancer differentiation and metastasis},
  author={Hongbin Ji and Matthew R. Ramsey and D. Neil Hayes and Cheng Fan and Kate L. McNamara and Piotr Kozlowski and Chad D Torrice and Michael C. Wu and Takeshi Shimamura and Samanthi A. Perera and M Liang and Dongpo Cai and George N. Naumov and Lei Bao and Cristina M. Contreras and Danan Li and Liang Chen and Janakiraman Krishnamurthy and Jussi Koivunen and Lucian R. Chirieac and Robert F Padera and Roderick Terry Bronson and Neal I Lindeman and David C. Christiani and Xihong Lin and Geoffrey I. Shapiro and Pasi Antero J{\"a}nne and Bruce Evan Johnson and Matthew Meyerson and David J Kwiatkowski and Diego H. Castrillon and Nabeel Bardeesy and Norman E Sharpless and Kwok-kin Wong},
  journal={Nature},
  year={2007},
  volume={448},
  pages={807-810}
}
Germline mutation in serine/threonine kinase 11 (STK11, also called LKB1) results in Peutz–Jeghers syndrome, characterized by intestinal hamartomas and increased incidence of epithelial cancers. Although uncommon in most sporadic cancers, inactivating somatic mutations of LKB1 have been reported in primary human lung adenocarcinomas and derivative cell lines. Here we used a somatically activatable mutant Kras-driven model of mouse lung cancer to compare the role of Lkb1 to other tumour… CONTINUE READING
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