LKB1 and AMPK regulate synaptic remodeling in old age

@article{Samuel2014LKB1AA,
  title={LKB1 and AMPK regulate synaptic remodeling in old age},
  author={Melanie A. Samuel and P. Emanuela Voinescu and Brendan N Lilley and Rafa de Cabo and Marc Foretz and Benoit Viollet and Basil S. Pawlyk and Michael A. Sandberg and Demetrios G Vavvas and Joshua R Sanes},
  journal={Nature Neuroscience},
  year={2014},
  volume={17},
  pages={1190-1197}
}
Age-related decreases in neural function result in part from alterations in synapses. To identify molecular defects that lead to such changes, we focused on the outer retina, in which synapses are markedly altered in old rodents and humans. We found that the serine/threonine kinase LKB1 and one of its substrates, AMPK, regulate this process. In old mice, synaptic remodeling was accompanied by specific decreases in the levels of total LKB1 and active (phosphorylated) AMPK. In the absence of… CONTINUE READING
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