LKB1 and AMPK: central regulators of lymphocyte metabolism and function.

  title={LKB1 and AMPK: central regulators of lymphocyte metabolism and function.},
  author={Julianna Blagih and Connie M Krawczyk and Russell G. Jones},
  journal={Immunological reviews},
  volume={249 1},
When T cells encounter foreign antigen and appropriate costimulatory signals from professional antigen-presenting cells (APCs), they initiate a coordinated program of rapid proliferation and differentiation, leading to the development of activated T cells with specific effector functions tailored toward pathogen clearance or control. One of the fundamental programs that underpin T-cell proliferation and function is the regulation of cellular metabolism. Recent efforts to identify the signal… CONTINUE READING
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