LKB1 — A master tumour suppressor of the small intestine and beyond

@article{Yoo2002LKB1A,
  title={LKB1 — A master tumour suppressor of the small intestine and beyond},
  author={Lina I. Yoo and Daniel C. Chung and Junying Yuan},
  journal={Nature Reviews Cancer},
  year={2002},
  volume={2},
  pages={529-535}
}
Peutz–Jeghers syndrome (PJS) is a rare, inherited intestinal polyposis syndrome that is associated with a significantly increased risk of several types of cancer — particularly those of the gastrointestinal and reproductive systems. Most cases of PJS have been associated with loss-of-function mutations in the ubiquitously expressed LKB1 gene, which encodes a serine/ threonine kinase. Recent studies have begun to illustrate the molecular mechanisms by which LKB1 functions as an important new… 

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