LKB1, the multitasking tumour suppressor kinase.

  title={LKB1, the multitasking tumour suppressor kinase.},
  author={Paola A. Marignani},
  journal={Journal of clinical pathology},
  volume={58 1},
Mutations in the lkb1 gene are found in Peutz-Jeghers syndrome (PJS), with loss of heterozygosity or somatic mutations at the lkb1 locus, suggesting the gene product, the serine/threonine kinase LKB1, may function as a tumour suppressor. Patients with PJS are at a greater risk of developing cancers of epithelial tissue origin. It is widely accepted that the presence of hamartomatous polyps in PJS does not in itself lead to the development of malignancy. The signalling mechanisms that lead to… CONTINUE READING


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