LKB1, a protein kinase regulating cell proliferation and polarity.

@article{Boudeau2003LKB1AP,
  title={LKB1, a protein kinase regulating cell proliferation and polarity.},
  author={J{\'e}r{\^o}me Boudeau and Gopal Sapkota and Dario R Alessi},
  journal={FEBS letters},
  year={2003},
  volume={546 1},
  pages={
          159-65
        }
}
LKB1 is a serine-threonine protein kinase mutated in patients with an autosomal dominantly inherited cancer syndrome predisposing to multiple benign and malignant tumours, termed Peutz-Jeghers syndrome. Since its discovery in 1998, much research has focused on identification and characterisation of its cellular roles and analysing how LKB1 might be regulated. In this review we discuss exciting recent advances indicating that LKB1 functions as a tumour suppressor perhaps by controlling cell… CONTINUE READING

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