LIP5 interacts with aquaporin 2 and facilitates its lysosomal degradation.

Abstract

Vasopressin binding to the V2 receptor in renal principal cells leads to activation of protein kinase A, phosphorylation of aquaporin 2 (AQP2) at Ser256, and the translocation of AQP2 to the apical membrane, resulting in concentration of the urine. In contrast, phorbol ester-induced activation of protein kinase C pathway leads to ubiquitination of AQP2 at… (More)
DOI: 10.1681/ASN.2008060648

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@article{Balkom2009LIP5IW, title={LIP5 interacts with aquaporin 2 and facilitates its lysosomal degradation.}, author={Bas W. M. van Balkom and Michelle Boone and Giel Hendriks and Erik-Jan Kamsteeg and Joris Henricus Robben and H. Christiaan Stronks and Anne van der Voorde and François van Herp and Peter van der Sluijs and Peter M T Deen}, journal={Journal of the American Society of Nephrology : JASN}, year={2009}, volume={20 5}, pages={990-1001} }