LINGO-1 negatively regulates TrkB phosphorylation after ocular hypertension.

  title={LINGO-1 negatively regulates TrkB phosphorylation after ocular hypertension.},
  author={Qing-ling Fu and Bing Hu and Xin Li and Zhaohui Shao and Jianbo Shi and Wutian Wu and Kwok-fai So and Sha Mi},
  journal={The European journal of neuroscience},
  volume={31 6},
The antagonism of LINGO-1, a CNS-specific negative regulator of neuronal survival, was shown to promote short-term survival of retinal ganglion cell (RGC) in an ocular hypertension model. LINGO-1 antagonists, combined with brain-derived neurotrophic factor (BDNF), can increase the length of neuron survival through an unclear molecular mechanism. To determine the relationship between LINGO-1 and BDNF/TrkB receptor in neuronal protection, we show here that LINGO-1 forms a receptor complex with… CONTINUE READING


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