LINE1 methylation levels associated with increased bladder cancer risk in pre-diagnostic blood DNA among US (PLCO) and European (ATBC) cohort study participants.

@article{Andreotti2014LINE1ML,
  title={LINE1 methylation levels associated with increased bladder cancer risk in pre-diagnostic blood DNA among US (PLCO) and European (ATBC) cohort study participants.},
  author={Gabriella Andreotti and Sara Karami and Ruth M. Pfeiffer and Lauren M Hurwitz and Linda M. Liao and Stephanie J Weinstein and Demetrius Albanes and Jarmo R Virtamo and Debra T. Silverman and Nathaniel Rothman and Lee E. Moore},
  journal={Epigenetics},
  year={2014},
  volume={9 3},
  pages={404-15}
}
Global methylation in blood DNA has been associated with bladder cancer risk in case-control studies, but has not been examined prospectively. We examined the association between LINE1 total percent 5-methylcytosine and bladder cancer risk using pre-diagnostic blood DNA from the United States-based, Prostate, Lung, Colorectal, Ovarian Cancer Screening Trial (PLCO) (299 cases/676 controls), and the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) cohort of Finnish male smokers (391 cases… CONTINUE READING
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