LINE-mediated retrotransposition of marked Alu sequences

@article{Dewannieux2003LINEmediatedRO,
  title={LINE-mediated retrotransposition of marked Alu sequences},
  author={M. Dewannieux and C{\'e}cile Esnault and T. Heidmann},
  journal={Nature Genetics},
  year={2003},
  volume={35},
  pages={41-48}
}
  • M. Dewannieux, Cécile Esnault, T. Heidmann
  • Published 2003
  • Medicine, Biology
  • Nature Genetics
  • Alu elements are the most successful transposons in humans. They are 300-bp non-coding sequences transcribed by RNA polymerase III (Pol III) and are expected to retrotranspose with the aid of reverse transcriptases of cellular origin. We previously showed that human LINEs can generate cDNA copies of any mRNA transcript by means of a retroposition process involving reverse transcription and integration by the LINE-encoded endonuclease and reverse transcriptase. Here we show mobility of marked… CONTINUE READING
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