LINE dancing in the human genome: transposable elements and disease

@inproceedings{Belancio2009LINEDI,
  title={LINE dancing in the human genome: transposable elements and disease},
  author={Victoria P. Belancio and Prescott L Deininger and Astrid M Roy-Engel},
  booktitle={Genome Medicine},
  year={2009}
}
Transposable elements (TEs) have been consistently underestimated in their contribution to genetic instability and human disease. TEs can cause human disease by creating insertional mutations in genes, and also contributing to genetic instability through non-allelic homologous recombination and introduction of sequences that evolve into various cis-acting signals that alter gene expression. Other outcomes of TE activity, such as their potential to cause DNA double-strand breaks or to modulate… CONTINUE READING
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