LINE-1 retrotransposons: modulators of quantity and quality of mammalian gene expression?

@article{Han2005LINE1RM,
  title={LINE-1 retrotransposons: modulators of quantity and quality of mammalian gene expression?},
  author={Jeffrey Han and Jef D. Boeke},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  year={2005},
  volume={27 8},
  pages={775-84}
}
LINE-1 (L1) retrotransposons are replicating repetitive elements that, by mass, are the most-abundant sequences in the human genome. Over one-third of mammalian genomes are the result, directly or indirectly, of L1 retrotransposition. L1 encodes two proteins: ORF1, an RNA-binding protein, and ORF2, an endonuclease/reverse transcriptase. Both proteins are required for L1 mobilization. Apart from the obvious function of self-replication, it is not clear what other roles, if any, L1 plays within… CONTINUE READING

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