LINE-1 hypomethylation is inversely associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer.

@article{Ogino2008LINE1HI,
  title={LINE-1 hypomethylation is inversely associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer.},
  author={Shuji Ogino and Takako Kawasaki and Katsuhiko Nosho and Mutsuko Ohnishi and Yuko Suemoto and Gregory J. Kirkner and Charles S. Fuchs},
  journal={International journal of cancer},
  year={2008},
  volume={122 12},
  pages={2767-73}
}
The CpG island methylator phenotype (CIMP) with widespread promoter CpG island methylation is a phenotype in colorectal cancer, associated with microsatellite instability (MSI) and BRAF mutation. Genome-wide hypomethylation may also play an important role in genomic instability. However, the relation between global DNA methylation level and methylation in individual CpG islands remains uncertain. Utilizing 869 population-based colorectal cancers, we measured long interspersed nucleotide element… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 140 extracted citations

Similar Papers

Loading similar papers…