LINE-1 hypomethylation induced by reactive oxygen species is mediated via depletion of S-adenosylmethionine.

@article{Kloypan2015LINE1HI,
  title={LINE-1 hypomethylation induced by reactive oxygen species is mediated via depletion of S-adenosylmethionine.},
  author={Chiraphat Kloypan and Monpicha Srisa-art and Apiwat Mutirangura and Chanchai Boonla},
  journal={Cell biochemistry and function},
  year={2015},
  volume={33 6},
  pages={375-85}
}
Whether long interspersed nuclear element-1 (LINE-1) hypomethylation induced by reactive oxygen species (ROS) was mediated through the depletion of S-adenosylmethionine (SAM) was investigated. Bladder cancer (UM-UC-3 and TCCSUP) and human kidney (HK-2) cell lines were exposed to 20 μM H2O2 for 72 h to induce oxidative stress. Level of LINE-1 methylation, SAM and homocysteine (Hcy) was measured in the H2O2 -exposed cells. Effects of α-tocopheryl acetate (TA), N-acetylcysteine (NAC), methionine… CONTINUE READING
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References

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S-Adenosylmethionine and methylation.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 1996
View 5 Excerpts
Highly Influenced

Folate deficiency and plasma homocysteine during increased oxidative stress.

The New England journal of medicine • 2007
View 4 Excerpts
Highly Influenced

Redox regulation of homocysteine-dependent glutathione synthesis.

Redox report : communications in free radical research • 2003
View 4 Excerpts
Highly Influenced

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