LINE-1 Activity in Facultative Heterochromatin Formation during X Chromosome Inactivation

@article{Chow2010LINE1AI,
  title={LINE-1 Activity in Facultative Heterochromatin Formation during X Chromosome Inactivation},
  author={Jennifer C. Chow and Constance Ciaudo and Melissa J. Fazzari and Nathan Mise and Nicolas Servant and Jacob L. Glass and Matthew Attreed and P. Avner and Anton Wutz and Emmanuel Barillot and John M. Greally and Olivier Voinnet and Edith Heard},
  journal={Cell},
  year={2010},
  volume={141},
  pages={956-969}
}
During X chromosome inactivation (XCI), Xist RNA coats and silences one of the two X chromosomes in female cells. Little is known about how XCI spreads across the chromosome, although LINE-1 elements have been proposed to play a role. Here we show that LINEs participate in creating a silent nuclear compartment into which genes become recruited. A subset of young LINE-1 elements, however, is expressed during XCI, rather than being silenced. We demonstrate that such LINE expression requires the… CONTINUE READING
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A novel role for Xist RNA in the formation of a repressive nuclear compartment into which genes are recruited when silenced

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