LINE-1: a human transposable element.

  title={LINE-1: a human transposable element.},
  author={M. F. Singer and V Krek and J. P. McMillan and Gary D. Swergold and R. E. Thayer},
  volume={135 1-2},
Among the 10(5) LINE-1 sequences (L1Hs) in the human genome are one or more 6-kb segments that are active retrotransposons. Expression of these retrotransposons appears to be favored in cells of germ line origin, as well as in some other tumor cells of epithelial origin. In such cells, the product of the first L1Hs open reading frame (ORF), a protein called p40, is detectable; p40 has no apparent similarity to gag proteins, but contains a leucine zipper region which may be responsible for the… CONTINUE READING
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