LINE‐1 retrotransposons: Modulators of quantity and quality of mammalian gene expression?

@article{Han2005LINE1RM,
  title={LINE‐1 retrotransposons: Modulators of quantity and quality of mammalian gene expression?},
  author={Jeffrey S. Han and Jef D. Boeke},
  journal={BioEssays},
  year={2005},
  volume={27}
}
LINE‐1 (L1) retrotransposons are replicating repetitive elements that, by mass, are the most‐abundant sequences in the human genome. Over one‐third of mammalian genomes are the result, directly or indirectly, of L1 retrotransposition. L1 encodes two proteins: ORF1, an RNA‐binding protein, and ORF2, an endonuclease/reverse transcriptase. Both proteins are required for L1 mobilization. Apart from the obvious function of self‐replication, it is not clear what other roles, if any, L1 plays within… 
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