LINCing lamin B2 to neuronal migration: growing evidence for cell-specific roles of B-type lamins.

@article{Coffinier2010LINCingLB,
  title={LINCing lamin B2 to neuronal migration: growing evidence for cell-specific roles of B-type lamins.},
  author={Catherine Coffinier and Loren G. Fong and Stephen G. Young},
  journal={Nucleus},
  year={2010},
  volume={1 5},
  pages={407-11}
}
Nuclear lamins are major components of the nuclear lamina, and play essential roles in supporting the nucleus and organizing nuclear structures. While a large number of clinically important mutations have been mapped to the LMNA gene in humans, very few mutations have been associated with the B-type lamins. We have shown that lamin B2-deficiency in mice results in severe brain abnormalities. While the early stages of forebrain development in lamin B2-deficient mice appear to be normal, cortical… CONTINUE READING
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