LINC00459 sponging miR-218 to elevate DKK3 inhibits proliferation and invasion in melanoma

  title={LINC00459 sponging miR-218 to elevate DKK3 inhibits proliferation and invasion in melanoma},
  author={Yuhua Yang and Wenxian Xu and Zhuojun Zheng and Zhihai Cao},
  journal={Scientific Reports},
The lncRNA biomarkers in melanoma remain to be further explored. The lncRNAs with different expression levels in melanoma tissue were identified by microarray analysis. To investigate the biological functions of target lncRNA, several in-vivo and in-vitro studies were performed. Potential mechanisms of competitive endogenous RNAs (ceRNAs) were predicted by using bioinformatics analysis and explored by western blot assay, fluorescence in situ hybridization assay, real-time quantitative PCR (RT… 

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