LIM-only protein FHL2 critically determines survival and radioresistance of pancreatic cancer cells.

Abstract

Numerous factors determine the current poor prognosis of pancreatic ductal adenocarcinoma (PDAC). One of the greatest challenges to overcome is treatment resistance. Among a large repertoire of intrinsic resistance mechanisms, integrin-mediated cell adhesion to extracellular matrix (ECM) has been identified to be fundamental. Coalesced in focal adhesion… (More)
DOI: 10.1016/j.canlet.2015.04.019

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