LIM kinase 1 promotes endothelial barrier disruption and neutrophil infiltration in mouse lungs.

@article{Gorovoy2009LIMK1,
  title={LIM kinase 1 promotes endothelial barrier disruption and neutrophil infiltration in mouse lungs.},
  author={Matvey S Gorovoy and Jingyan Han and Haiyun Pan and Emily J Welch and Radu Florin Neamu and Zhengping Jia and Dan N. Predescu and Stephen Vogel and Richard D Minshall and Richard D Ye and Asrar B. Malik and Tatyana A. Voyno-Yasenetskaya},
  journal={Circulation research},
  year={2009},
  volume={105 6},
  pages={549-56}
}
RATIONALE Disruption of endothelial barrier function and neutrophil-mediated injury are two major mechanisms underlying the pathophysiology of sepsis-induced acute lung injury (ALI). Recently we reported that endotoxin induced activation of RhoA in mice lungs that led to the disruption of endothelial barrier and lung edema formation; however, the molecular mechanism of this phenomenon remained unknown. OBJECTIVE We reasoned that LIMK1, which participates in the regulation of endothelial cell… CONTINUE READING

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