LIM-homeobox gene 2 promotes tumor growth and metastasis by inducing autocrine and paracrine PDGF-B signaling.

@article{Kuzmanov2014LIMhomeoboxG2,
  title={LIM-homeobox gene 2 promotes tumor growth and metastasis by inducing autocrine and paracrine PDGF-B signaling.},
  author={Aleksandar Kuzmanov and Ulrike Hopfer and Patricia Marti and Nathalie Meyer-Schaller and Mahmut Yilmaz and Gerhard Christofori},
  journal={Molecular oncology},
  year={2014},
  volume={8 2},
  pages={401-16}
}
An epithelial-mesenchymal transition (EMT) is a critical process during embryonic development and the progression of epithelial tumors to metastatic cancers. Gene expression profiling has uncovered the transcription factor LIM homeobox gene 2 (Lhx2) with up-regulated expression during TGFβ-induced EMT in normal and cancerous breast epithelial cells. Loss and gain of function experiments in transgenic mouse models of breast cancer and of insulinoma in vivo and in breast cancer cells in vitro… CONTINUE READING

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