LIM domain-binding 1 maintains the terminally differentiated state of pancreatic β cells.


The recognition of β cell dedifferentiation in type 2 diabetes raises the translational relevance of mechanisms that direct and maintain β cell identity. LIM domain-binding protein 1 (LDB1) nucleates multimeric transcriptional complexes and establishes promoter-enhancer looping, thereby directing fate assignment and maturation of progenitor populations… (More)
DOI: 10.1172/JCI88016


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