LIGHT-deficiency impairs CD8+ T cell expansion, but not effector function.

  title={LIGHT-deficiency impairs CD8+ T cell expansion, but not effector function.},
  author={Jinqi Liu and Clint S. Schmidt and Feisha Zhao and Angela J Okragly and Andrew L. Glasebrook and Niles Fox and Elizabeth Galbreath and Qing Yong Zhang and Ho Yeong Song and Songqing Na and Derek Yang},
  journal={International immunology},
  volume={15 7},
LIGHT, a newly identified member of the tumor necrosis factor (TNF) family, is expressed on activated T lymphocytes. To evaluate how LIGHT contributes to T cell functions, we generated LIGHT-deficient (LIGHT(-/-)) mice using gene targeting. Disruption of LIGHT significantly reduced CD8(+) T cell-cycle progression, leading to reduced proliferation to anti-CD3, anti-CD3/anti-CD28 or allogeneic stimulation, whereas proliferation of CD4(+) T cells remained unchanged. In contrast to the observed… CONTINUE READING
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