LIG4 mediates Wnt signalling-induced radioresistance

  title={LIG4 mediates Wnt signalling-induced radioresistance},
  author={Sohee Jun and Youn-Sang Jung and Han Na Suh and Wenqi Wang and Moon Jong Kim and Young Sun Oh and Esther M. Lien and Xi Shen and Yoshihisa Matsumoto and P. D. Mccrea and Lei Li and Junjie Chen and Jae-Il Park},
  booktitle={Nature communications},
Despite the implication of Wnt signalling in radioresistance, the underlying mechanisms are unknown. Here we find that high Wnt signalling is associated with radioresistance in colorectal cancer (CRC) cells and intestinal stem cells (ISCs). We find that LIG4, a DNA ligase in DNA double-strand break repair, is a direct target of β-catenin. Wnt signalling enhances non-homologous end-joining repair in CRC, which is mediated by LIG4 transactivated by β-catenin. During radiation-induced intestinal… CONTINUE READING


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