LIF receptor signaling limits immune-mediated demyelination by enhancing oligodendrocyte survival

@article{Butzkueven2002LIFRS,
  title={LIF receptor signaling limits immune-mediated demyelination by enhancing oligodendrocyte survival},
  author={Helmut Butzkueven and Jian Gong Zhang and Merja Soilu-Hanninen and Hubertus Hochrein and Fiona Chionh and Kylie A. Shipham and Ben Emery and Ann M Turnley and Steven Petratos and Matthias Ernst and Perry F. Bartlett and Trevor J. Kilpatrick},
  journal={Nature Medicine},
  year={2002},
  volume={8},
  pages={613-619}
}
Multiple sclerosis (MS) is a disabling inflammatory demyelinating disease of the central nervous system (CNS) that primarily affects young adults. Available therapies can inhibit the inflammatory component of MS but do not suppress progressive clinical disability. An alternative approach would be to inhibit mechanisms that drive the neuropathology of MS, which often includes the death of oligodendrocytes, the cells responsible for myelinating the CNS. Identification of molecular mechanisms that… CONTINUE READING
Highly Influential
This paper has highly influenced 10 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 99 extracted citations

Exogenous leukemia inhibitory factor stimulates oligodendrocyte progenitor cell proliferation and enhances hippocampal remyelination.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2012
View 6 Excerpts
Highly Influenced

Interleukin-11 potentiates oligodendrocyte survival and maturation, and myelin formation.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2006
View 7 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 44 references

Association of a null mutation in the CNTF gene with early onset of multiple sclerosis

R. Giess
Arch . Neurol . • 2002

Defective gp130mediated STAT signalling results in degenerative joint disease , gastrointestinal ulceration and failure of uterine impantation

M. Ernst
J . Exp . Med . • 2001

Similar Papers

Loading similar papers…