LIF receptor signaling limits immune-mediated demyelination by enhancing oligodendrocyte survival

@article{Butzkueven2002LIFRS,
  title={LIF receptor signaling limits immune-mediated demyelination by enhancing oligodendrocyte survival},
  author={H. Butzkueven and J. Zhang and Merja Soilu-Hanninen and H. Hochrein and F. Chionh and K. A. Shipham and B. Emery and A. Turnley and S. Petratos and M. Ernst and P. Bartlett and T. Kilpatrick},
  journal={Nature Medicine},
  year={2002},
  volume={8},
  pages={613-619}
}
  • H. Butzkueven, J. Zhang, +9 authors T. Kilpatrick
  • Published 2002
  • Medicine
  • Nature Medicine
  • Multiple sclerosis (MS) is a disabling inflammatory demyelinating disease of the central nervous system (CNS) that primarily affects young adults. Available therapies can inhibit the inflammatory component of MS but do not suppress progressive clinical disability. An alternative approach would be to inhibit mechanisms that drive the neuropathology of MS, which often includes the death of oligodendrocytes, the cells responsible for myelinating the CNS. Identification of molecular mechanisms that… CONTINUE READING
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    Publications referenced by this paper.
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