LIF is a contraction-induced myokine stimulating human myocyte proliferation.

@article{Broholm2011LIFIA,
  title={LIF is a contraction-induced myokine stimulating human myocyte proliferation.},
  author={Christa Broholm and Matthew J. Laye and Claus Brandt and Radhika Vadalasetty and Henriette Pilegaard and Bente Klarlund Pedersen and Camilla C. Scheele},
  journal={Journal of applied physiology},
  year={2011},
  volume={111 1},
  pages={251-9}
}
The cytokine leukemia inhibitory factor (LIF) is expressed by skeletal muscle and induces proliferation of myoblasts. We hypothesized that LIF is a contraction-induced myokine functioning in an autocrine fashion to activate gene regulation of human muscle satellite cell proliferation. Skeletal muscle LIF expression, regulation, and action were examined in two models: 1) young men performing a bout of heavy resistance exercise of the quadriceps muscle and 2) cultured primary human satellite… CONTINUE READING
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