LHX6 acts as a novel potential tumour suppressor with epigenetic inactivation in lung cancer

@inproceedings{Liu2013LHX6AA,
  title={LHX6 acts as a novel potential tumour suppressor with epigenetic inactivation in lung cancer},
  author={W-b Liu and Xupin Jiang and Fei Han and Y-h Li and H-q Chen and Ying-xi Liu and Jian Cao and J-y Liu},
  booktitle={Cell Death and Disease},
  year={2013}
}
LIM homeobox domain 6 (LHX6) is a putative transcriptional regulator that controls the differentiation and development of neural and lymphoid cells. However, the function of LHX6 in cancer development remains largely unclear. Recently, we found that LHX6 is hypermethylated in lung cancer. In this study, we analysed its epigenetic regulation, biological functions, and related molecular mechanisms in lung cancer. Methylation status was evaluated by methylation-specific PCR and bisulfite genomic… CONTINUE READING