LHRH-conjugated Magnetic Iron Oxide Nanoparticles for Detection of Breast Cancer Metastases

@article{Leuschner2006LHRHconjugatedMI,
  title={LHRH-conjugated Magnetic Iron Oxide Nanoparticles for Detection of Breast Cancer Metastases},
  author={Carola Leuschner and Challa S. S. R. Kumar and William Hansel and Winston Oluwole Soboyejo and Jikou Zhou and Josef Hormes},
  journal={Breast Cancer Research and Treatment},
  year={2006},
  volume={99},
  pages={163-176}
}
Targeted delivery of superparamagnetic iron oxide nanoparticles (SPIONs) could facilitate their accumulation in metastatic cancer cells in peripheral tissues, lymph nodes and bones and enhance the sensitivity of magnetic resonance imaging (MRI). The specificities of luteinizing hormone releasing hormone (LHRH) and luteinizing hormone/chorionic gonadotropin (LH/CG)- bound SPIONs were tested in human breast cancer cells in vitro and were found to be dependent on the receptor expression of the… CONTINUE READING