LHRH antagonist attenuates the effect of fluoxetine on marble-burying behavior in mice.

@article{Uday2007LHRHAA,
  title={LHRH antagonist attenuates the effect of fluoxetine on marble-burying behavior in mice.},
  author={Gaikwad Uday and Bhutada Pravinkumar and Wanjari Manish and Umathe Sudhir},
  journal={European journal of pharmacology},
  year={2007},
  volume={563 1-3},
  pages={155-9}
}
Leuprolide--a luteinizing hormone-releasing hormone (LHRH) agonist, dose dependently (100, 200 and 300 microg/kg, s.c.) inhibited marble-burying behavior in mice, which was comparable to that of fluoxetine (10 and 15 mg/kg, i.p.)--a drug used in the treatment of obsessive-compulsive disorder. Co-administration of sub-effective dose of leuprolide (50 microg/kg) and fluoxetine (5 mg/kg) significantly inhibited marble-burying-behavior. Pre-treatment with parachlorophenylalanine [300 mg/kg, i.p… CONTINUE READING

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