LHRH and GTP-gamma-S modify calcium current activation in bullfrog sympathetic neurons.

@article{Elmslie1990LHRHAG,
  title={LHRH and GTP-gamma-S modify calcium current activation in bullfrog sympathetic neurons.},
  author={Keith Elmslie and Wei Zhou and Stephen W. Jones},
  journal={Neuron},
  year={1990},
  volume={5 1},
  pages={75-80}
}
LHRH (chicken II luteinizing hormone-releasing hormone) partially reduces calcium currents and slows the activation kinetics of part of the remaining current in frog sympathetic neurons. The effects of LHRH are mimicked by intracellular dialysis with GTP-gamma-S. A strong depolarization can temporarily reverse the effects of LHRH or GTP-gamma-S: activation kinetics return to normal, and the amplitude of the current is increased (facilitation). Facilitation develops rapidly (tau = 4-6 ms at… CONTINUE READING
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