LH induces orphan nuclear receptor Nur77 gene expression in testicular Leydig cells.

@article{Song2001LHIO,
  title={LH induces orphan nuclear receptor Nur77 gene expression in testicular Leydig cells.},
  author={K H Song and Jin Ill Park and Mi Ock Lee and J W Soh and Keesook Lee and Hueng Sik Choi},
  journal={Endocrinology},
  year={2001},
  volume={142 12},
  pages={5116-23}
}
The orphan nuclear receptor Nur77 (NR4A1) is a member of the nuclear receptor superfamily and plays an important role in the regulation of genes involved in steroidogenesis and cell death. Northern blot analysis revealed that the expression of Nur77 mRNA was increased after puberty in mouse testis, and hCG treatment of peripubertal animals induced this gene expression in the testis. Moreover, LH treatment induced a transient increase in Nur77 mRNA, and this induction was LH dose dependent in… CONTINUE READING
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