LGR5-positive colon cancer stem cells interconvert with drug-resistant LGR5-negative cells and are capable of tumor reconstitution.

@article{Kobayashi2012LGR5positiveCC,
  title={LGR5-positive colon cancer stem cells interconvert with drug-resistant LGR5-negative cells and are capable of tumor reconstitution.},
  author={Shinta Kobayashi and Hisafumi Yamada-Okabe and Masami Suzuki and Osamu Natori and Atsuhiko Kato and Koichi Matsubara and Yu Jau Chen and Masaki Yamazaki and Shinichi Funahashi and Kenji Yoshida and Eri Hashimoto and Yoshinori Watanabe and Hironori Mutoh and Motooki Ashihara and Chie Kato and Takeshi Watanabe and Takashi Yoshikubo and Norikazu Tamaoki and Takahiro Ochiya and Masahiko Kuroda and Arnold J. Levine and Tatsumi Yamazaki},
  journal={Stem cells},
  year={2012},
  volume={30 12},
  pages={2631-44}
}
The cancer stem cell (CSC) concept has been proposed as an attractive theory to explain cancer development, and CSCs themselves have been considered as targets for the development of diagnostics and therapeutics. However, many unanswered questions concerning the existence of slow cycling/quiescent, drug-resistant CSCs remain. Here we report the establishment of colon cancer CSC lines, interconversion of the CSCs between a proliferating and a drug-resistant state, and reconstitution of tumor… CONTINUE READING
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