LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling.

@article{Glinka2011LGR4AL,
  title={LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling.},
  author={Andrei Glinka and Christine E. Dolde and Nadine Kirsch and Ya-Lin Huang and Olga Kazanskaya and Dierk Ingelfinger and Michael Boutros and Cristina-Maria Cruciat and Christof Niehrs},
  journal={EMBO reports},
  year={2011},
  volume={12 10},
  pages={1055-61}
}
R-spondins are secreted Wnt signalling agonists, which regulate embryonic patterning and stem cell proliferation, but whose mechanism of action is poorly understood. Here we show that R-spondins bind to the orphan G-protein-coupled receptors LGR4 and LGR5 by their Furin domains. Gain- and loss-of-function experiments in mammalian cells and Xenopus embryos indicate that LGR4 and LGR5 promote R-spondin-mediated Wnt/β-catenin and Wnt/PCP signalling. R-spondin-triggered β-catenin signalling… CONTINUE READING
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