LGL leukemia and HTLV.

  title={LGL leukemia and HTLV.},
  author={Anish Thomas and Raisa Perzova and Lynn Abbott and Patricia M. Benz and Michael J Poiesz and Syamalima Dube and Thomas Loughran and Jorge Ferrer and William A. Sheremata and Jordan B. Glaser and Matilde Leon-Ponte and Bernard J Poiesz},
  journal={AIDS research and human retroviruses},
  volume={26 1},
Samples were obtained from 53 large granular lymphocytic leukemia (LGLL) patients and 10,000 volunteer blood donors (VBD). Sera were screened in an HTLV-1 enzyme immunoassay (EIA) and further analyzed in peptide-specific Western blots (WB). DNAs were analyzed by HTLV-1, -2, -3, and -4-specific PCR. Forty four percent of LGLL patients vs. 0.12 % of VBD had anti-HTLV antibodies via EIA (p < 0.001). WB and PCR revealed that four LGLL patients (7.5%) vs. one VBD patient (0.01%) were infected with… CONTINUE READING