LGL leukemia: from pathogenesis to treatment.

  title={LGL leukemia: from pathogenesis to treatment.},
  author={Thierry Lamy and Aline Moignet and Thomas P. Loughran},
  volume={129 9},
Large granular lymphocyte (LGL) leukemia has been recognized by the World Health Organization classifications amongst mature T-cell and natural killer (NK) cell neoplasms. There are 3 categories: chronic T-cell leukemia and NK-cell lymphocytosis, which are similarly indolent diseases characterized by cytopenias and autoimmune conditions as opposed to aggressive NK-cell LGL leukemia. Clonal LGL expansion arise from chronic antigenic stimulation, which promotes dysregulation of apoptosis, mainly… CONTINUE READING
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Population-based analyses BLOOD, 2 MARCH 2017 x VOLUME 129, NUMBER 9 LGL LEUKEMIA: OVERVIEW

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  • For personal use only. on December
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