LFR1 ferric iron reductase of Leishmania amazonensis is essential for the generation of infective parasite forms.

@article{Flannery2011LFR1FI,
  title={LFR1 ferric iron reductase of Leishmania amazonensis is essential for the generation of infective parasite forms.},
  author={Andrew R. Flannery and Chau Huynh and Bidyottam Mittra and Renato Arruda Mortara and Norma W Andrews},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 26},
  pages={23266-79}
}
The protozoan parasite Leishmania is the causative agent of serious human infections worldwide. The parasites alternate between insect and vertebrate hosts and cause disease by invading macrophages, where they replicate. Parasites lacking the ferrous iron transporter LIT1 cannot grow intracellularly, indicating that a plasma membrane-associated mechanism for iron uptake is essential for the establishment of infections. Here, we identify and functionally characterize a second member of the… CONTINUE READING