LFP-20, a porcine lactoferrin peptide, ameliorates LPS-induced inflammation via the MyD88/NF-κB and MyD88/MAPK signaling pathways.

@article{Zong2015LFP20AP,
  title={LFP-20, a porcine lactoferrin peptide, ameliorates LPS-induced inflammation via the MyD88/NF-κB and MyD88/MAPK signaling pathways.},
  author={Xin Zong and Deguang Song and Tenghao Wang and Xi Xia and Wangyang Hu and Feifei Han and Yizhen Wang},
  journal={Developmental and comparative immunology},
  year={2015},
  volume={52 2},
  pages={123-31}
}
LFP-20 is one of the 20 amino acid anti-microbial peptides identified in the N terminus of porcine lactoferrin. Apart from its extensively studied direct anti-bacterial activity, its potential as an activator of immune-related cellular functions is unknown. Therefore, this study investigated its anti-inflammatory effects in lipopolysaccharide (LPS)-stimulated pig alveolar macrophages in vitro and systemic inflammation in an in vivo mouse model. We found that the inhibitory effects of LFP-20 on… CONTINUE READING
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