LFA-1 and Mac-1 integrins bind to the serine/threonine-rich domain of thrombomodulin.

Abstract

LFA-1 (αLβ2) and Mac-1 (αMβ2) integrins regulate leukocyte trafficking in health and disease by binding primarily to IgSF ligand ICAM-1 and ICAM-2 on endothelial cells. Here we have shown that the anti-coagulant molecule thrombomodulin (TM), found on the surface of endothelial cells, functions as a potentially new ligand for leukocyte integrins. We… (More)
DOI: 10.1016/j.bbrc.2016.04.007

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Cite this paper

@article{Kawamoto2016LFA1AM, title={LFA-1 and Mac-1 integrins bind to the serine/threonine-rich domain of thrombomodulin.}, author={Eiji Kawamoto and Takayuki Okamoto and Yoshimi Takagi and Goichi Honda and Koji Suzuki and Hiroshi Imai and Motomu Shimaoka}, journal={Biochemical and biophysical research communications}, year={2016}, volume={473 4}, pages={1005-1012} }